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Home » Uncategorized » Team 206: Establishing the Design Space of a Bioreactor with ANSYS Fluent on Microsoft Azure

Team 206: Establishing the Design Space of a Bioreactor with ANSYS Fluent on Microsoft Azure

Team 205Bioreactors are the heart of every pharmaceutical manufacturing process. One goal of a bioreactor is to operate at process conditions that provide sufficient oxygen to the suspended cells. The design space of a bioreactor defines the relationship between the input and output parameters of the cell culture process and typically relies on a design of experiments (DOE) approach to characterize the inter-dependencies between tank design and process operating conditions. The pharmaceutical industry has adopted CFD modeling as a cost-saving option. However, the simulation time and compute resources required to explore the relationships between various process parameters can be quite extensive. This case study reviews the use of HPC to establish the design space of a production-scale sparged bioreactor. The simulation framework is developed and executed on Azure Cloud resources running the ANSYS Fluent UberCloud container. Read the case study HERE.

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